CCL17-neutralizing and esterase-responsive core-shell microgels for endogenous Tregs recruitment and functional enhancement in myocardial infarction
Liang Song, Yongyuan Kang, Pai Peng, Qiaoxuan Wang, Shuqin Wang, Liyin Shen, Jinyue Zhang, Yang Zhu, Changyou Gao · 2026
Read CCL17-neutralizing and esterase-responsive core-shell microgels for endogenous Tregs recruitment and functional enhancement in myocardial infarction by Liang Song, Yongyuan Kang, Pai Peng, Qiaoxuan Wang, Shuqin Wang, Liyin Shen, Jinyue Zhang, Yang Zhu, Changyou Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292248.txt.
Description
Liang Song and co-authors engineer a 2026 treatment platform of core-shell microgels meant to heal the immune imbalance after a heart attack. Infarction leaves regulatory T cells scarce and weak near the damage. The microgel surface carries an antibody that neutralizes CCL17, a signal that misdirects those cells, while the core holds a prodrug that releases propionic acid when enzymes cleave it.
In lab tests, the platform drew in 4.2 times more regulatory T cells and raised their Foxp3 expression by 1.8 times over baseline measures. In mouse heart attack models, cell infiltration into the injured region rose 2.4 times while Th17 cells fell in the treated hearts. Heart function improved and scarring shrank. The authors pitch the system as local immune repair for infarcted tissue.
Catalog record
| CREATOR | Liang Song, Yongyuan Kang, Pai Peng, Qiaoxuan Wang, Shuqin Wang, Liyin Shen, Jinyue Zhang, Yang Zhu, Changyou Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83890 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |