Neutrophil extracellular trap (NET)-related index as an indicator of periprosthetic joint infection
Tingrun Cui, Yongjian Liang, Zeyu Feng, Libo Hao, Guoqiang Zhang, Ming Ni, Jing Sheng, Dihua Shangguan, Jiying Chen, Jun Fu · 2026
Read Neutrophil extracellular trap (NET)-related index as an indicator of periprosthetic joint infection by Tingrun Cui, Yongjian Liang, Zeyu Feng, Libo Hao, Guoqiang Zhang, Ming Ni, Jing Sheng, Dihua Shangguan, Jiying Chen, Jun Fu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292152.txt.
Description
Tingrun Cui and co-authors test a 2026 diagnostic idea for infected artificial joints: reading neutrophil extracellular traps in joint fluid. These web-like structures spill from neutrophils during infection and are hard to judge with standard tests alone. The retrospective study covered arthroplasty patients from 2018 to 2023, measuring three trap components alongside cell counts and cultures.
Of 153 patients, 64 had confirmed infections. Two trap markers, cell-free DNA and citrullinated histone H3, ran much higher in infected fluid and tracked with white cell counts. A combined index the authors call NETRI reached an area under the curve of 0.922 in their analysis. One-marker positivity suited screening, while two-marker positivity, at 95.5 percent specificity in the data, suited ruling infection in. The authors propose trap testing as a fresh discriminator.
Catalog record
| CREATOR | Tingrun Cui, Yongjian Liang, Zeyu Feng, Libo Hao, Guoqiang Zhang, Ming Ni, Jing Sheng, Dihua Shangguan, Jiying Chen, Jun Fu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34606 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |