A New Paradigm of Bispecific Antibodies in Clinical Management of Gastrointestinal Cancers
Huimin Zhao, Xiuran Wang, Zhimeng Fan, Ai Sun, Changhua Zhang, Chunhui Sun · 2026
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Description
Huimin Zhao and co-authors survey a 2026 shift in gut cancer care: bispecific antibodies that grab two targets at once. Cancers of the gut and digestive organs carry a heavy global burden and often shrug off single-drug therapy. The review ranges over colorectal, gastric, pancreatic, biliary, esophageal, and liver cancers, naming key targets and lead candidates such as CEA-TCB and RG7802.
Strategies include reshaping the suppressive tissue around tumors and pairing them with chemotherapy or checkpoint blockers. The authors also discuss how AI might predict targets and refine antibody structures. Harms such as cytokine release syndrome and off-tumor toxicity remain real obstacles, as does tumor diversity. Proposed fixes include affinity tuning, conditional activation, and biomarker-guided patient selection.
Catalog record
| CREATOR | Huimin Zhao, Xiuran Wang, Zhimeng Fan, Ai Sun, Changhua Zhang, Chunhui Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93654 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |