Prognostic Value of Spatial and Topological Features of Tumor Microenvironment in Classic Hodgkin Lymphoma
Irene Bernal-Florindo, Jose Angel Raposo-Puglia, Felix A. Ruiz, Jose Perez-Requena, Cristian Benavides-de la Fuente, Javier Galan, Maria Jose Berruezo-Salazar, Marcial Garcia-Rojo, Cecilia Fernandez-Ponce, Antonio Santisteban-Espejo · 2026
Read Prognostic Value of Spatial and Topological Features of Tumor Microenvironment in Classic Hodgkin Lymphoma by Irene Bernal-Florindo, Jose Angel Raposo-Puglia, Felix A. Ruiz, Jose Perez-Requena, Cristian Benavides-de la Fuente, Javier Galan, Maria Jose Berruezo-Salazar, Marcial Garcia-Rojo, Cecilia Fernandez-Ponce, Antonio Santisteban-Espejo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292054.txt.
Description
Irene Bernal-Florindo and co-authors review a 2026 body of work on reading prognosis in classic Hodgkin lymphoma from the tumor microenvironment's layout. Between 10 and 20 percent of patients never reach complete response, and standard clinical variables do not explain why. The review follows the shift from manual pathology toward digital image analysis and computational pathology.
Software now counts tumor and immune cells objectively and maps how they sit in relation to one another. The authors argue that spatial and topological features carry prognostic value beyond cell counts alone. They sketch future models blending those features with liquid biopsy sequencing, single-cell data, spatial transcriptomics, and PET/CT imaging. The goal is sharper risk groups and treatments matched to each patient's tumor ecology.
Catalog record
| CREATOR | Irene Bernal-Florindo, Jose Angel Raposo-Puglia, Felix A. Ruiz, Jose Perez-Requena, Cristian Benavides-de la Fuente, Javier Galan, Maria Jose Berruezo-Salazar, Marcial Garcia-Rojo, Cecilia Fernandez-Ponce, Antonio Santisteban-Espejo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42615 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |