EBF1 Deficiency Drives Prostate Cancer Progression by Interfering with the Transcriptional Regulation of ITPR1
Yuan Guo, Hui Wang, Xiaoyu Zhao, Xiao Feng, Xingjian Cai, Wei Li, Xiaohui Luo · 2026
Read EBF1 Deficiency Drives Prostate Cancer Progression by Interfering with the Transcriptional Regulation of ITPR1 by Yuan Guo, Hui Wang, Xiaoyu Zhao, Xiao Feng, Xingjian Cai, Wei Li, Xiaohui Luo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291987.txt.
Description
Yuan Guo and co-authors investigate a 2026 cancer biology study on EBF1, a transcription factor first known for guiding B-cell development, in prostate cancer. Database analyses and tissue staining linked low EBF1 levels with worse disease course. The team then dialed EBF1 down or up in prostate cancer cell lines and in a mouse xenograft model.
Silencing EBF1 made LNCaP and 22RV1 cells grow, form colonies, migrate, and invade more aggressively. Forcing extra EBF1 into PC-3 cells did the opposite, slowing tumor growth and invasion. Molecular assays pointed to EBF1 controlling the gene for ITPR1, a calcium channel receptor, as part of the mechanism. The authors frame EBF1 loss as a driver of prostate cancer progression worth further study.
Catalog record
| CREATOR | Yuan Guo, Hui Wang, Xiaoyu Zhao, Xiao Feng, Xingjian Cai, Wei Li, Xiaohui Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55958 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |