Efficient Derivation and Transcriptional Characterization of Mouse Extra‐Embryonic Endoderm Stem Cell Lines Generated by Somatic Cell Nuclear Transfer
Shuaipeng Li, Shu Wei, Guomeng Li, Mei Hu, Jiangwei Lin, Wandong Bao · 2026
Read Efficient Derivation and Transcriptional Characterization of Mouse Extra‐Embryonic Endoderm Stem Cell Lines Generated by Somatic Cell Nuclear Transfer by Shuaipeng Li, Shu Wei, Guomeng Li, Mei Hu, Jiangwei Lin, Wandong Bao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291796.txt.
Description
Shuaipeng Li and co-authors announce a 2026 stem cell study reporting the first extra-embryonic endoderm stem cell lines made from cloned mouse embryos. Cloning by nuclear transfer works poorly, partly because reprogramming goes wrong, and cloned lines already existed for embryonic and trophoblast stem cells but not for this endoderm lineage. The team derived the new lines from nuclear-transfer blastocysts.
Hybrid embryos yielded lines at 55 percent efficiency, close to the 50 percent rate for fertilized embryos, while an inbred strain managed only 12.5 percent of attempts succeeding. The cloned lines switched on endoderm markers such as Gata4, Gata6, and Sox17, and their gene patterns closely matched fertilized counterparts. A handful of differing genes hint the cloned cells may lean slightly toward a more developed state.
Catalog record
| CREATOR | Shuaipeng Li, Shu Wei, Guomeng Li, Mei Hu, Jiangwei Lin, Wandong Bao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31026 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |