Use of Prokinetic Agents in Adult ICU Patients: An International Inception Cohort Study (PATIENCE)
Vera Crone, Morten Hylander Møller, Anders Granholm, Anders Perner, Waleed Alhazzani, Laura Rindom Krogsgaard, Abdulrahman Al‐Fares, Johanna Hästbacka, Marlies Ostermann, Carmen A Pfortmueller, Ricard Ferrer, Annika Reintam Blaser, Olof Wall, Eric Keus, Wojciech Szczeklik, Peter Martin Hansen, Jens Michelsen, Mikkel Bak, Lise Skyttegaard Balkert, Tino Severinsen, Anne Craveiro Brøchner, Jonas Elmer Pedersen, Anne Sofie Andreasen, Camilla Tageby Nielsen, Theis Skovsgaard Itenov, Maj‐Brit Nørregaard Kjær, Zemira Engbakken, Morten Heiberg Bestle, Peter Buhl Hjortrup, Christian Juhl Svendsen, Sandra Lindkvist‐Viggers, Björn Anders Brand, Andreas Bender Jonsson, Tobias Browall Krogh, Kristian Reinhold Jauho, Mathias Sinkbæk Thomsen, Therese Simonsen Straarup, Eva Poulsen, Christian Gade Nissen, Olena Breum · 2026
Read Use of Prokinetic Agents in Adult ICU Patients: An International Inception Cohort Study (PATIENCE) by Vera Crone, Morten Hylander Møller, Anders Granholm, Anders Perner, Waleed Alhazzani, Laura Rindom Krogsgaard, Abdulrahman Al‐Fares, Johanna Hästbacka, Marlies Ostermann, Carmen A Pfortmueller, Ricard Ferrer, Annika Reintam Blaser, Olof Wall, Eric Keus, Wojciech Szczeklik, Peter Martin Hansen, Jens Michelsen, Mikkel Bak, Lise Skyttegaard Balkert, Tino Severinsen, Anne Craveiro Brøchner, Jonas Elmer Pedersen, Anne Sofie Andreasen, Camilla Tageby Nielsen, Theis Skovsgaard Itenov, Maj‐Brit Nørregaard Kjær, Zemira Engbakken, Morten Heiberg Bestle, Peter Buhl Hjortrup, Christian Juhl Svendsen, Sandra Lindkvist‐Viggers, Björn Anders Brand, Andreas Bender Jonsson, Tobias Browall Krogh, Kristian Reinhold Jauho, Mathias Sinkbæk Thomsen, Therese Simonsen Straarup, Eva Poulsen, Christian Gade Nissen, Olena Breum (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291764.txt.
Description
Crone and co-authors map the worldwide use of gut stimulating drugs in intensive care in this 2026 PATIENCE study. Feeding intolerance is common in critically ill patients, and prokinetic agents are given to move the gut along. Evidence for them is thin, so practice varies. The team followed newly admitted patients in 56 intensive care units across 11 countries.
Among 1440 patients, 187 received a prokinetic agent during their stay, roughly one patient in eight. Metoclopramide was the drug used most often. Patients who had undergone abdominal surgery before were more likely to receive one. Use of these drugs came with a higher hazard of serious adverse events and fewer days alive out of intensive care and hospital, though not with higher 90 day mortality. Crone presents the figures as a baseline for future trials.
Catalog record
| CREATOR | Vera Crone, Morten Hylander Møller, Anders Granholm, Anders Perner, Waleed Alhazzani, Laura Rindom Krogsgaard, Abdulrahman Al‐Fares, Johanna Hästbacka, Marlies Ostermann, Carmen A Pfortmueller, Ricard Ferrer, Annika Reintam Blaser, Olof Wall, Eric Keus, Wojciech Szczeklik, Peter Martin Hansen, Jens Michelsen, Mikkel Bak, Lise Skyttegaard Balkert, Tino Severinsen, Anne Craveiro Brøchner, Jonas Elmer Pedersen, Anne Sofie Andreasen, Camilla Tageby Nielsen, Theis Skovsgaard Itenov, Maj‐Brit Nørregaard Kjær, Zemira Engbakken, Morten Heiberg Bestle, Peter Buhl Hjortrup, Christian Juhl Svendsen, Sandra Lindkvist‐Viggers, Björn Anders Brand, Andreas Bender Jonsson, Tobias Browall Krogh, Kristian Reinhold Jauho, Mathias Sinkbæk Thomsen, Therese Simonsen Straarup, Eva Poulsen, Christian Gade Nissen, Olena Breum |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |