Beyond PRP: Recognizing the Evolving Generations of Platelet Concentrates in Androgenetic Alopecia Treatment—A Letter in Response to Zhong Et al
Luo Ruiyu, Zhao Changjiang, Li Yufei · 2026
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Description
Writing to the editor in 2026, Luo Ruiyu, Zhao Changjiang, and Li Yufei respond to a review by Zhong and colleagues on platelet-rich plasma for pattern hair loss. The letter argues that platelet concentrate technology has moved well past that first product. The authors lay out a generational sequence that clinicians may find more useful.
Second-generation platelet-rich fibrin dropped anticoagulants and forms a fibrin scaffold that releases growth factors slowly. Third-generation concentrated growth factor, spun at variable speeds, holds dense fibrin and CD34+ progenitor cells. A newer purified fraction keeps mainly tiny vesicles and exosomes, which may act through microRNA signals that shape hair follicle cycling. The letter closes by noting early signs of better injection comfort with that fraction.
Catalog record
| CREATOR | Luo Ruiyu, Zhao Changjiang, Li Yufei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3693 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |