Breastmilk transfer of cabotegravir and infant safety outcomes in mothers on cabotegravir for HIV prevention in Lilongwe, Malawi: A protocol for an observational pharmacokinetic study, CABMILK Study
Mphatso S. Kantonya, Clifford G. Banda, Mayamiko D. Kapulula, Steven Munharo, Hellen D. Chavula, Vincent K. Phiri, Diksha Patel, Friday Saidi, Mina Hosseinipour, Fiona Cresswell, Catriona Waitt, Victor Mwapasa, Lisa Abuogi, Stephen Ian Walimbwa, Stefano Rusconi, Lisa Abuogi, Mphatso Kantonya · 2026
Read Breastmilk transfer of cabotegravir and infant safety outcomes in mothers on cabotegravir for HIV prevention in Lilongwe, Malawi: A protocol for an observational pharmacokinetic study, CABMILK Study by Mphatso S. Kantonya, Clifford G. Banda, Mayamiko D. Kapulula, Steven Munharo, Hellen D. Chavula, Vincent K. Phiri, Diksha Patel, Friday Saidi, Mina Hosseinipour, Fiona Cresswell, Catriona Waitt, Victor Mwapasa, Lisa Abuogi, Stephen Ian Walimbwa, Stefano Rusconi, Lisa Abuogi, Mphatso Kantonya (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291744.txt.
Description
Mphatso S Kantonya and colleagues describe the CABMILK study protocol from Lilongwe, Malawi, in 2026. Long-acting injectable cabotegravir prevents HIV well, given every two months. Breastfeeding mothers were left out of the drug's early safety studies. How much drug passes into milk, and what infants absorb, remains unknown. CABMILK will measure that transfer inside two rollout programs in Malawi.
One hundred mother-infant pairs will enroll across three groups. Twenty-five mothers use the injection, twenty-five use daily oral prevention pills, and fifty use no prevention drug. Blood and milk samples will be assayed to compute milk-to-plasma ratios and infant exposure. Babies will be followed for eight months with growth checks and a development index. Adverse events will be recorded for each group. The authors expect the data to guide safe policy for breastfeeding women in high-burden settings.
Catalog record
| CREATOR | Mphatso S. Kantonya, Clifford G. Banda, Mayamiko D. Kapulula, Steven Munharo, Hellen D. Chavula, Vincent K. Phiri, Diksha Patel, Friday Saidi, Mina Hosseinipour, Fiona Cresswell, Catriona Waitt, Victor Mwapasa, Lisa Abuogi, Stephen Ian Walimbwa, Stefano Rusconi, Lisa Abuogi, Mphatso Kantonya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 101523 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |