Structural and cellular insights into DCTPP1 antagonists and their synergistic action with DNMT inhibitors
Glenn Hauk, Jianyong Liu, William G. Nelson, Srinivasan Yegnasubramanian, James M. Berger · 2026
Read Structural and cellular insights into DCTPP1 antagonists and their synergistic action with DNMT inhibitors by Glenn Hauk, Jianyong Liu, William G. Nelson, Srinivasan Yegnasubramanian, James M. Berger (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291643.txt.
Description
Blocking one cleanup enzyme may boost a cancer drug class. Glenn Hauk leads a 2026 study of DCTPP1 blockers. The enzyme chews up altered DNA building blocks. That chewing weakens analog drugs used against cancer.
A mass screen hunted compounds that jam the enzyme. New and known classes showed strong submicromolar power. Crystal images showed all blockers in the same pocket. Two key residues grip each blocker in place. Tweaked scaffolds confirmed the grip model. Lead blockers paired with decitabine in prostate cells. Growth blocking grew far stronger in the pair. Gene tests proved the boost needs the enzyme.
Catalog record
| CREATOR | Glenn Hauk, Jianyong Liu, William G. Nelson, Srinivasan Yegnasubramanian, James M. Berger |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44653 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |