SPP1 and MMP1 as key therapeutic targets of Jingfang Granule in idiopathic pulmonary fibrosis: integrated bioinformatics and machine learning analysis
Yifan Ren, Jingzhe Gao, Kunshuang Shen, Shan Jiang, Yaoyu Xie, Yuanyuan Wang, Xiaoran Sun, Yaoai Wang, Ning Zhang, Siju Lou, Jiaxin Ding, Bingxu Mu, Guangli Yan, Guimin Zhang, Xijun Wang · 2026
Read SPP1 and MMP1 as key therapeutic targets of Jingfang Granule in idiopathic pulmonary fibrosis: integrated bioinformatics and machine learning analysis by Yifan Ren, Jingzhe Gao, Kunshuang Shen, Shan Jiang, Yaoyu Xie, Yuanyuan Wang, Xiaoran Sun, Yaoai Wang, Ning Zhang, Siju Lou, Jiaxin Ding, Bingxu Mu, Guangli Yan, Guimin Zhang, Xijun Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291481.txt.
Description
A Chinese herbal mix may fight lung scarring disease. Yifan Ren leads a 2026 computer and lab study of Jingfang Granule. The disease, idiopathic pulmonary fibrosis, kills slowly. Few drug options exist for patients today.
Public gene data on the disease were mined first. Thousands of genes shifted in sick lung tissue. Network tools linked herb targets to disease targets. Five learning methods hunted for marker genes. Two genes, SPP1 and MMP1, stood out as key. Docking tests checked how herb parts bind them. Tissue stains backed the computer findings. The pair may guide new drug design for this disease.
Catalog record
| CREATOR | Yifan Ren, Jingzhe Gao, Kunshuang Shen, Shan Jiang, Yaoyu Xie, Yuanyuan Wang, Xiaoran Sun, Yaoai Wang, Ning Zhang, Siju Lou, Jiaxin Ding, Bingxu Mu, Guangli Yan, Guimin Zhang, Xijun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69757 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |