Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer
Cunen Wu, Yuanyuan Xu, Ming Zhao, Lihuiping Tao, Dayue Darrel Duan, Jun Qian, Shumin Zhao, Shenlin Liu, Jin-yong Zhou · 2026
Read Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer by Cunen Wu, Yuanyuan Xu, Ming Zhao, Lihuiping Tao, Dayue Darrel Duan, Jun Qian, Shumin Zhao, Shenlin Liu, Jin-yong Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291139.txt.
Description
Immune maps inside colon tumors are built by Cunen Wu and colleagues in a 2026 study. Colorectal cancer helps only some patients with immunotherapy. Gene patterns that track drug response are needed. Single-cell and spatial data were joined here.
Cells numbered 27,414 from tumor and normal tissue. Natural killer T cell types were mapped in detail. Spatial data showed them beside Th1 helper cells. Tumors rich in these cells fared better. Drug sensitivity also ran higher in such tumors. A gene score was built from both cell types. Nine cohorts tested that score with care. High scores marked distinct tumor traits.
Catalog record
| CREATOR | Cunen Wu, Yuanyuan Xu, Ming Zhao, Lihuiping Tao, Dayue Darrel Duan, Jun Qian, Shumin Zhao, Shenlin Liu, Jin-yong Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48797 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |