HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload
Konstantin Hennis, Julia Rilling, Linh Pham, René Rötzer, Chiara Piantoni, Yakun Wu, Nicolas Auerbach, Jürgen Groher, Daniela Kruck, Stefan Koplitz-Weißgerber, Christian Gruner, Andreas Scharr, Verena Mehlfeld, Martin Biel, Christian Wahl-Schott, Stefanie Fenske · 2026
Read HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload by Konstantin Hennis, Julia Rilling, Linh Pham, René Rötzer, Chiara Piantoni, Yakun Wu, Nicolas Auerbach, Jürgen Groher, Daniela Kruck, Stefan Koplitz-Weißgerber, Christian Gruner, Andreas Scharr, Verena Mehlfeld, Martin Biel, Christian Wahl-Schott, Stefanie Fenske (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13291042.txt.
Description
Konstantin Hennis leads a 2026 mouse study of a heart rhythm gene change. The change makes the HCN4 channel overactive. In people, such changes link to a fast resting heartbeat. Chronic fast rhythm is feared as a heart harm driver.
Mutant mice showed higher resting heart rates. Their electrical conduction also ran faster. No rhythm faults appeared on their own. Heart tissue showed no harm from the fast rate. Under pressure load, mutant hearts resisted bad remodeling. That result defies the simple fear story. A fast pacemaker need not damage the heart, it seems.
Catalog record
| CREATOR | Konstantin Hennis, Julia Rilling, Linh Pham, René Rötzer, Chiara Piantoni, Yakun Wu, Nicolas Auerbach, Jürgen Groher, Daniela Kruck, Stefan Koplitz-Weißgerber, Christian Gruner, Andreas Scharr, Verena Mehlfeld, Martin Biel, Christian Wahl-Schott, Stefanie Fenske |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45496 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |