The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study
Yongqi Ding, Xiaomei Dong, Qi Wang, Tianchao Xu · 2026
Read The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study by Yongqi Ding, Xiaomei Dong, Qi Wang, Tianchao Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13290851.txt.
Description
Childhood emotional neglect may deepen adult depression partly through body-wide inflammation, Yongqi Ding and colleagues report in a study from 2026. They tested whether a combined blood marker sits on the path between early neglect and how bad depression gets in major depressive disorder.
The study enrolled 236 patients who filled in trauma and mood surveys and gave routine blood tests. Patients with childhood trauma histories showed higher inflammation and worse depression. Among trauma types, neglect predicted depression scores most strongly, and among blood markers the combined index predicted best of all. A mediation analysis assigned about 28% of the neglect-to-severity link to that index. Ding and colleagues stress the design cannot prove cause, but flag inflammation-lowering add-on treatments as worth testing in future trials.
Catalog record
| CREATOR | Yongqi Ding, Xiaomei Dong, Qi Wang, Tianchao Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37330 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |