CD25+CD27+CD70− alloantigen-specific Tregs: promising stable immunotherapy for transplantation
Arimelek Cortés-Hernández, Saúl Arteaga-Cruz, Iyari I. Martínez Iturbe, Katya Rosas-Cortina, Marco A. Vigil Mora, Erick Legorreta-Anguiano, Judith E. Reyes Barrientos, Evelyn K. Álvarez-Salazar, Alejandra Cervera, Beatriz E. Sánchez-Hernández, Armando Gamboa Domínguez, Gloria Soldevila · 2026
Read CD25+CD27+CD70− alloantigen-specific Tregs: promising stable immunotherapy for transplantation by Arimelek Cortés-Hernández, Saúl Arteaga-Cruz, Iyari I. Martínez Iturbe, Katya Rosas-Cortina, Marco A. Vigil Mora, Erick Legorreta-Anguiano, Judith E. Reyes Barrientos, Evelyn K. Álvarez-Salazar, Alejandra Cervera, Beatriz E. Sánchez-Hernández, Armando Gamboa Domínguez, Gloria Soldevila (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13290811.txt.
Description
Transplant tolerance may get stabler soldiers: Arimelek Cortés-Hernández and colleagues describe in 2026 a recipe for growing donor-specific regulatory T cells that keep their identity. Such cells are rare in blood, hard to purify, and prone to drift during long expansion, which has stalled their clinical use.
The protocol first grows regulatory T cells with donor dendritic cells plus interleukin-15, interleukin-2, and retinoic acid, then sorts the CD25+CD27+CD70− subset and expands it with antibody stimulation, rapamycin, and TGF-β. Three weeks yielded a 434-fold expansion at over 95% purity, with the FOXP3 stability marker largely demethylated. The cells suppressed T cell growth in a donor-specific way even after inflammatory challenge and made none of the inflammatory cytokines that signal drift. Cortés-Hernández and colleagues nominate them for long-term transplant tolerance therapy.
Catalog record
| CREATOR | Arimelek Cortés-Hernández, Saúl Arteaga-Cruz, Iyari I. Martínez Iturbe, Katya Rosas-Cortina, Marco A. Vigil Mora, Erick Legorreta-Anguiano, Judith E. Reyes Barrientos, Evelyn K. Álvarez-Salazar, Alejandra Cervera, Beatriz E. Sánchez-Hernández, Armando Gamboa Domínguez, Gloria Soldevila |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69866 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |