The safety and efficacy of human umbilical cord mesenchymal stem cell for acute respiratory distress syndrome: an open-label and multicenter phase 1 clinical trial
Qinggang Ge, Libo Zheng, Man Zhao, Chao Li, Zhiling Zhao, Zongyu Wang, Qiang Zhang, Mai Shi, Yuxuan Li, Jianan Zhang, Yixian Qiao, Senhao Wei, Ning Shen, Haomiao Long, Yongjun Liu, Jie Qiao · 2026
Read The safety and efficacy of human umbilical cord mesenchymal stem cell for acute respiratory distress syndrome: an open-label and multicenter phase 1 clinical trial by Qinggang Ge, Libo Zheng, Man Zhao, Chao Li, Zhiling Zhao, Zongyu Wang, Qiang Zhang, Mai Shi, Yuxuan Li, Jianan Zhang, Yixian Qiao, Senhao Wei, Ning Shen, Haomiao Long, Yongjun Liu, Jie Qiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13290605.txt.
Description
Umbilical cord stem cells proved safe in a first human trial for acute respiratory distress syndrome, Qinggang Ge and colleagues report in 2026. ARDS kills heavily and has few specific treatments, so the team ran an open-label, multicenter phase 1 study of an intravenous cell product called BC-U001.
Twelve patients with mild-to-moderate ARDS entered a 3+3 dose-escalation scheme run from 2019 to 2024 and got one infusion on top of standard care. No dose-limiting toxicity or treatment-related severe events appeared, and 28-day mortality was 8.3%, one patient of twelve in the trial. The middle dose group improved most on oxygen measures and organ-failure scores, though gains did not rise with dose. Ge and colleagues say the safety readout justifies large randomized trials.
Catalog record
| CREATOR | Qinggang Ge, Libo Zheng, Man Zhao, Chao Li, Zhiling Zhao, Zongyu Wang, Qiang Zhang, Mai Shi, Yuxuan Li, Jianan Zhang, Yixian Qiao, Senhao Wei, Ning Shen, Haomiao Long, Yongjun Liu, Jie Qiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49000 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |