Long-read sequencing for cancer liquid biopsy: advancing precision oncology
Grace Guzman, Analiz Rodriguez · 2026
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Description
Long-read sequencing could catch what short reads miss in blood-based cancer tests, Grace Guzman and Analiz Rodriguez argue in a 2026 mini-review. Liquid biopsy reads tumor material shed into body fluids, but the standard short-read approach struggles with structural variants, phasing, fusion transcripts, and methylation marks.
The authors survey studies applying long-read platforms, including single-molecule real-time and nanopore sequencing, to cell-free and circulating tumor DNA. Work is most active in lung, brain, and pediatric cancers, where long reads have surfaced structural changes, methylation patterns, and tumor-of-origin signals beyond short-read reach. Barriers remain: variable sample handling, cost, and heavy computing demands. Guzman and Rodriguez expect long reads to join multimodal liquid biopsy panels rather than replace them.
Catalog record
| CREATOR | Grace Guzman, Analiz Rodriguez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27076 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |