Molecular and spatial specialization of lung interstitial macrophage subsets: beyond chemokines
Xin Li, Claudia V. Jakubzick · 2026
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Description
Where lung macrophages sit shapes what they do, Xin Li and Claudia Jakubzick show in a 2026 study of mouse interstitial macrophages. These tissue-resident immune cells help keep the lung in balance and organize its defenses, and earlier work had split them into CD206-high and CD206-low families.
Combining full transcript profiles with Xenium spatial mapping, the pair charted the gene programs of each subset and where each one lives. The two families carried distinct cytokine, receptor, and innate-defense signatures, plus a predicted self-signaling network. In tissue, the cells clustered in bronchovascular bundles, the interstitium, and the lung periphery, each subset favoring its own niche and showing matching adhesion and enzyme patterns. Chemokine production also varied by location, lining up with where T and B cells position themselves.
Catalog record
| CREATOR | Xin Li, Claudia V. Jakubzick |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70839 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |