Combination of metformin and parthenolide inhibits breast cancer in mice by apoptosis induction and angiogenesis inhibition
Raghad K. Alomari, Moudi M Alasmari, Heba K Alshaeri, Alexandra Makai, Wamidh H Talib, Márta Hock · 2026
Read Combination of metformin and parthenolide inhibits breast cancer in mice by apoptosis induction and angiogenesis inhibition by Raghad K. Alomari, Moudi M Alasmari, Heba K Alshaeri, Alexandra Makai, Wamidh H Talib, Márta Hock (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13290444.txt.
Description
Pairing the diabetes drug metformin with the plant compound parthenolide hit breast cancer harder than either alone, Raghad Alomari and colleagues report in 2026. Both agents had shown anticancer hints separately; this study tested them together in cells and in mice.
Against three breast cancer cell lines, the combination interacted synergistically to slow growth. In mice carrying EMT6/P tumors, combined treatment shrank tumors significantly, cured half the animals, and caused no treatment-related deaths. Tumor tissue showed more caspase-3-driven apoptosis and less VEGF, pointing to cell suicide plus choked blood supply as the mechanisms, and blood markers of liver and kidney damage stayed normal. Alomari and colleagues call for deeper mechanistic work toward clinical testing.
Catalog record
| CREATOR | Raghad K. Alomari, Moudi M Alasmari, Heba K Alshaeri, Alexandra Makai, Wamidh H Talib, Márta Hock |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45081 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |