Guilu Erxian Glue Restores Immune Homeostasis in Aplastic Anemia Mice by Regulating Treg Lineage Stability via the miRNA-17/10a and FasL/Fas Signaling Pathways
Song Sun, Boyang Meng, Jinghao Sang, Wei Liu, Yingkai Zhang, Deze Li, Dongyang Li, Pingxin Zhang, Jingmin Niu, Jie Wei, Limin Chai · 2026
Read Guilu Erxian Glue Restores Immune Homeostasis in Aplastic Anemia Mice by Regulating Treg Lineage Stability via the miRNA-17/10a and FasL/Fas Signaling Pathways by Song Sun, Boyang Meng, Jinghao Sang, Wei Liu, Yingkai Zhang, Deze Li, Dongyang Li, Pingxin Zhang, Jingmin Niu, Jie Wei, Limin Chai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13290390.txt.
Description
A traditional formula, Guilu Erxian Glue, steadied the immune system of mice with aplastic anemia in a 2026 study by Song Sun and colleagues. Aplastic anemia is bone marrow failure driven in part by misdirected T-cell attack.
The team first mined patient data to find misregulated microRNAs, landing on miRNA-17-5p and miRNA-10a-5p. They then profiled the formula's chemistry and tested it in a mouse model built with irradiation and donor lymphocytes. Treated mice showed better marrow structure and restored blood counts. Harmful T-cell subsets fell while regulatory T cells rose, and the authors link the effect to the two microRNA pathways and Fas signaling. Sun and colleagues present the formula, given with standard immunosuppression, as a candidate for restoring immune balance in this disease.
Catalog record
| CREATOR | Song Sun, Boyang Meng, Jinghao Sang, Wei Liu, Yingkai Zhang, Deze Li, Dongyang Li, Pingxin Zhang, Jingmin Niu, Jie Wei, Limin Chai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70685 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |