mTORC2-Nav1.2 signaling drives early hyperexcitability in Alzheimer’s disease mouse model
Nolan M. Dvorak, Jeffrey L. Noebels · 2026
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Description
Writing in 2026, Nolan Dvorak and Jeffrey Noebels describe a signaling pathway that makes brain cells overactive early in Alzheimer's disease. Their study links the protein complex mTORC2 to the sodium channel Nav1.2 in a mouse model of the disease.
The authors show that overactive mTOR signaling boosts Nav1.2 channel function, and that this effect needs mTORC2 and does not extend to other major brain sodium channels. In the mouse model, cortical pyramidal neurons showed the same raised channel activity and excess firing. Because overactivity appears before heavy damage and speeds later decline, the mTORC2 and Nav1.2 pairing is put forward as a drug target for early treatment.
Catalog record
| CREATOR | Nolan M. Dvorak, Jeffrey L. Noebels |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80907 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |