Osteogenic Differentiation Induced by Dental Pulp Stem Cells Secretome: A Dose‐Dependent Comparative Study
Mahdi Kadkhodazadeh, Reza Amid, Aida Kheiri, Sayna Shamszadeh, Forough Shams · 2026
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Description
Mahdi Kadkhodazadeh and colleagues study fluid collected from dental pulp stem cells as a bone signal, in 2026. The fluid, called conditioned medium, carries the cells' secreted factors without the cells themselves. Periodontal ligament stem cells were bathed in three strengths of the medium. The team tracked growth, movement, and bone-forming activity over fourteen days. Tests ran in plain growth medium and in bone-promoting medium.
The lowest strength, ten percent, worked best across most measures. It raised growth factor release, cell growth, and bone markers more than stronger mixes did. Movement peaked early for both the lowest and middle strengths. Adding the fluid to bone medium gave the strongest bone induction of all. The pattern fits hormesis, where a small dose helps and larger doses add inhibitory factors. The authors say dose tuning is essential before clinical use of such secretome products.
Catalog record
| CREATOR | Mahdi Kadkhodazadeh, Reza Amid, Aida Kheiri, Sayna Shamszadeh, Forough Shams |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |