Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury
Lin Tu, Yuming Lu, Xingde Liu, Xiangchun Shen · 2026
Read Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury by Lin Tu, Yuming Lu, Xingde Liu, Xiangchun Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13289659.txt.
Description
Lin Tu, Yuming Lu, Xingde Liu, and Xiangchun Shen tested a 2026 plant compound, salvianic acid A, for heart injury when blood flow returns after a blockage. That return injury, called ischemia-reperfusion harm, involves ferroptosis, an iron-driven cell death. The compound is known for heart protection, and the team traced whether it works through a chain involving EGFR, Nrf2, and GPX4 proteins.
Cell tests under low oxygen then reoxygenation measured reactive oxygen, iron, and defense molecules alongside ferroptosis signs. The compound lowered harmful oxidants and iron while raising protective GPX4 and related defenses. Blocking Nrf2 or silencing EGFR erased the benefit, proving the chain matters. Animal heart injury also eased with treatment.
Catalog record
| CREATOR | Lin Tu, Yuming Lu, Xingde Liu, Xiangchun Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82047 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |