Topological optimization synergized with a high-activity nano-hydroxyapatite coating to enhance bone regeneration in a porous titanium alloy scaffold
Peng Zhao, Yushuan Jia, Jingming Li, Fengyi You, Kai Zhang, Bo Yuan, Xiangdong Zhu · 2026
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Description
Zhao and six co-authors pair shape optimization with a mineral coating to help titanium scaffolds grow bone, in a study from twenty twenty-six. Printed porous titanium is strong but its surface is inert, which invites scar tissue. The team shapes the pore lattice with fluid simulations for good flow. They then coat it evenly with a thin bone-like mineral layer.
The coating boosts stem cell sticking, growth, and bone differentiation. In dog muscle tests, one lattice shape spurs bone formation best. Its deep fluid flow and even shear stress explain the edge. In rabbit thigh bone defects, the tuned scaffold bonds tightly to bone and fills with new bone. The design may improve clinical implants.
Catalog record
| CREATOR | Peng Zhao, Yushuan Jia, Jingming Li, Fengyi You, Kai Zhang, Bo Yuan, Xiangdong Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |