Long-term polystyrene nanoplastics exposure aggravates retinal inflammation and photoreceptor degeneration through microglial SPP1 signaling and neutrophil extracellular traps formation
Wenchuan Zhou, Xuanyi Chen, Jiagen Li, Jincan He · 2026
Read Long-term polystyrene nanoplastics exposure aggravates retinal inflammation and photoreceptor degeneration through microglial SPP1 signaling and neutrophil extracellular traps formation by Wenchuan Zhou, Xuanyi Chen, Jiagen Li, Jincan He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13289438.txt.
Description
Wenchuan Zhou, Xuanyi Chen, Jiagen Li, and Jincan He report a 2026 mouse and cell study on nanoplastic harm to the retina. Tiny polystyrene particles can now reach body tissues, yet eye effects were little known. The team asked whether long exposure worsens light-sensing cell loss after retinal detachment, a separation of the retina from its support layer.
Mice drank water with particles for two months before detachment surgery, while lab co-cultures combined immune and light-sensing cells under stress. Particles crossed the blood-retina barrier and worsened oxidative stress and cell death in a dose-linked way. Immune cells of the retina switched on a signal called SPP1, and web-like traps from neutrophils added harm. Blocking those paths was tested by eye injections.
Catalog record
| CREATOR | Wenchuan Zhou, Xuanyi Chen, Jiagen Li, Jincan He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54016 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |