Melanoma cell states shape spatial tumor-immune ecosystems to dictate the efficacy of anti-PD1 immunotherapy
Félix K Pham, Marion Dufeu, Valentin Benboubker, Maxime Grimont, Amélie Lhorisson, Justine Berthet, Marie Donzel, Raphaël Schneider, Laurie Tonon, Anne-Claire Doffin, Félix Boivin, Simon Durand, Bertrand Dubois, Jonathan Lopez, Christophe Caux, Jenny Valladeau-Guilemond, Anaïs Eberhardt, Stéphane Dalle, Julie Caramel · 2026
Read Melanoma cell states shape spatial tumor-immune ecosystems to dictate the efficacy of anti-PD1 immunotherapy by Félix K Pham, Marion Dufeu, Valentin Benboubker, Maxime Grimont, Amélie Lhorisson, Justine Berthet, Marie Donzel, Raphaël Schneider, Laurie Tonon, Anne-Claire Doffin, Félix Boivin, Simon Durand, Bertrand Dubois, Jonathan Lopez, Christophe Caux, Jenny Valladeau-Guilemond, Anaïs Eberhardt, Stéphane Dalle, Julie Caramel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13289303.txt.
Description
Félix K Pham and colleagues published a 2026 study on how melanoma cell states shape immune neighborhoods and response to anti-PD-1 therapy. Nearly half of patients resist these immune drugs, even though melanoma often responds well. Tumor cells can shift form, and that plasticity may help them evade immune attack in distinct ways.
Tumors came from 57 people with stage III disease, sampled before adjuvant anti-PD-1 care and split by relapse within two years. Slides with many stains plus spatial gene mapping in four cases charted tumor patches, T cells, macrophages, dendritic cells, and lymphoid clusters. Groups of like tumor cells formed tight patches. The team defined a plasticity ratio from patch types to link layout with relapse risk and immune layout.
Catalog record
| CREATOR | Félix K Pham, Marion Dufeu, Valentin Benboubker, Maxime Grimont, Amélie Lhorisson, Justine Berthet, Marie Donzel, Raphaël Schneider, Laurie Tonon, Anne-Claire Doffin, Félix Boivin, Simon Durand, Bertrand Dubois, Jonathan Lopez, Christophe Caux, Jenny Valladeau-Guilemond, Anaïs Eberhardt, Stéphane Dalle, Julie Caramel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79254 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |