PD-1 and TIGIT coexpression enables selective enrichment of clonally expanded tumor-reactive CD8 T cells for melanoma TIL therapy
Kathleen Ducoin, Tiffany Beauvais, James Goward, Mawuena Ahondo, Sylvia Lambot, Aurélie Mordelet, Anaïs Daminette, Morane Thabot, Jixin Deng, Song Tian, Samuel Rulli, Gaëlle Quereux, Amir Khammari, Nathalie Labarrière · 2026
Read PD-1 and TIGIT coexpression enables selective enrichment of clonally expanded tumor-reactive CD8 T cells for melanoma TIL therapy by Kathleen Ducoin, Tiffany Beauvais, James Goward, Mawuena Ahondo, Sylvia Lambot, Aurélie Mordelet, Anaïs Daminette, Morane Thabot, Jixin Deng, Song Tian, Samuel Rulli, Gaëlle Quereux, Amir Khammari, Nathalie Labarrière (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13289266.txt.
Description
Kathleen Ducoin and colleagues report a 2026 study on picking better killer T cells for melanoma therapy. Some patients do not respond to anti-PD-1 drugs, so teams try adoptive cell therapy using tumor-infiltrating lymphocytes, or TILs, grown from the tumor itself. Success varies, in part because only some infused cells truly target the cancer.
The team focused on CD8 T cells carrying both PD-1 and TIGIT, a pair they call DPOS. Deep immune profiling, receptor sequencing, lab tests, and mouse models with patient tumors showed these cells were rich in melanoma-specific killers. They carried signs of activation and tissue residence yet could still multiply well. A sorting and growth workflow fit for clinic use was built, offering a path to stronger, more focused cell products.
Catalog record
| CREATOR | Kathleen Ducoin, Tiffany Beauvais, James Goward, Mawuena Ahondo, Sylvia Lambot, Aurélie Mordelet, Anaïs Daminette, Morane Thabot, Jixin Deng, Song Tian, Samuel Rulli, Gaëlle Quereux, Amir Khammari, Nathalie Labarrière |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59444 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |