Mapping the TCR landscape: computational tools empowering translational immunology and therapy design
Pâmella Borges, Martiela Vaz de Freitas, Jinkyung Yoo, Finn Beruldsen, Jaila Lewis, Francisca Joseli Freitas de Sousa, Sae Hee Choi, Duy Bao Nguyen, Geancarlo Zanatta, Jeong Hoon Jang, Eduardo Donadi, Houda Alachkar, Steven P Wolf, Maurício Menegatti Rigo, Hyeongseon Jeon, Dinler Amaral Antunes · 2026
Read Mapping the TCR landscape: computational tools empowering translational immunology and therapy design by Pâmella Borges, Martiela Vaz de Freitas, Jinkyung Yoo, Finn Beruldsen, Jaila Lewis, Francisca Joseli Freitas de Sousa, Sae Hee Choi, Duy Bao Nguyen, Geancarlo Zanatta, Jeong Hoon Jang, Eduardo Donadi, Houda Alachkar, Steven P Wolf, Maurício Menegatti Rigo, Hyeongseon Jeon, Dinler Amaral Antunes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13289238.txt.
Description
Pâmella Borges and many coauthors published a 2026 review of computer tools for studying T cell receptors. These receptors let T cells recognize targets and drive adaptive immunity. New sequencing methods now produce huge receptor datasets from blood and tissue, in bulk or one cell at a time, and software must make sense of them.
The review sorts more than 40 tools into six stages, framed around cancer immune therapy. Early stages cover getting data and rebuilding receptor parts, including the gene segments and binding loops. Later stages cover grouping similar receptors, modeling their three-dimensional shape with targets, and guessing what each receptor binds. Readers get a practical workflow for choosing tools and linking receptor patterns to treatment response.
Catalog record
| CREATOR | Pâmella Borges, Martiela Vaz de Freitas, Jinkyung Yoo, Finn Beruldsen, Jaila Lewis, Francisca Joseli Freitas de Sousa, Sae Hee Choi, Duy Bao Nguyen, Geancarlo Zanatta, Jeong Hoon Jang, Eduardo Donadi, Houda Alachkar, Steven P Wolf, Maurício Menegatti Rigo, Hyeongseon Jeon, Dinler Amaral Antunes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63328 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |