A chimeric trivalent Echovirus vaccine designed by loop substitution elicits cross-neutralizing immunity against serotypes 11, 18, and 30
Shuai Jiang, Jiaqi Cui, Tao Sun, Jiahuang Li, Heming Li, Tianlun Chen, Jiahui Wu, Zhenhua Zheng, Jianbo Xia, Chunchen Wu, Jie Wu · 2026
Read A chimeric trivalent Echovirus vaccine designed by loop substitution elicits cross-neutralizing immunity against serotypes 11, 18, and 30 by Shuai Jiang, Jiaqi Cui, Tao Sun, Jiahuang Li, Heming Li, Tianlun Chen, Jiahui Wu, Zhenhua Zheng, Jianbo Xia, Chunchen Wu, Jie Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13289168.txt.
Description
Shuai Jiang and a team of co-authors design a vaccine that guards against three types of echovirus at once, in a paper dated twenty twenty-six. Echoviruses spread widely and can cause brain lining infection, heart swelling, and grave illness in newborns. Many types exist, which makes one vaccine hard to build. The team focused on three common types, numbered eleven, eighteen, and thirty.
They mapped the parts of a shell protein that antibodies target most. Then they grafted loops from two types onto the frame of the third, keeping the natural shape. Both a protein vaccine and an mRNA vaccine built from this design made mice produce antibodies that blocked all three types. The work backs shape-guided grafting as a route to broad vaccines.
Catalog record
| CREATOR | Shuai Jiang, Jiaqi Cui, Tao Sun, Jiahuang Li, Heming Li, Tianlun Chen, Jiahui Wu, Zhenhua Zheng, Jianbo Xia, Chunchen Wu, Jie Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |