Subthalamic CaMKIIα-expressing neurons facilitate recovery from propofol anesthesia via the STN–ventral pallidum pathway
Shangqin Bai, Yiqiu Chen, Yu Li, Xiao Liu, Yanyan Ba, Qingbin Chen, Xiangqing Song, Haisheng Zhang, Xiaochun Lai, Lin Xue, Pei Sun, He Zhu, Jingyu Xiao, Wen Li, Xuejun Wang · 2026
Read Subthalamic CaMKIIα-expressing neurons facilitate recovery from propofol anesthesia via the STN–ventral pallidum pathway by Shangqin Bai, Yiqiu Chen, Yu Li, Xiao Liu, Yanyan Ba, Qingbin Chen, Xiangqing Song, Haisheng Zhang, Xiaochun Lai, Lin Xue, Pei Sun, He Zhu, Jingyu Xiao, Wen Li, Xuejun Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13287289.txt.
Description
Shangqin Bai and a large team study a set of neurons in the subthalamic nucleus that may speed waking from propofol anesthesia. These CaMKIIα-expressing neurons had been linked to arousal and pain, but their role in anesthesia was unclear. Brain and muscle signals, calcium recording and cell markers tracked their activity in mice.
Activity of these neurons fell sharply under propofol. Turning them on with light or chemical tools raised cortical arousal and cut recovery time, without changing how fast anesthesia began. Tracing found a direct path from the subthalamic nucleus to the ventral pallidum. Stimulating that path's ends also aided waking, marking it as a possible target for tuning recovery.
Catalog record
| CREATOR | Shangqin Bai, Yiqiu Chen, Yu Li, Xiao Liu, Yanyan Ba, Qingbin Chen, Xiangqing Song, Haisheng Zhang, Xiaochun Lai, Lin Xue, Pei Sun, He Zhu, Jingyu Xiao, Wen Li, Xuejun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |