Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder
Cristina M. Justice, Kwangmi Ahn, Benjamin Jung, Luke J. Norman, Gustavo Sudre, Wendy Sharp, Marine Bouyssi-Kobar, Saadia Choudhury, Stevi Gligorovic, Paul Kundzicz, Maria T. Acosta, Philip Shaw · 2026
Read Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder by Cristina M. Justice, Kwangmi Ahn, Benjamin Jung, Luke J. Norman, Gustavo Sudre, Wendy Sharp, Marine Bouyssi-Kobar, Saadia Choudhury, Stevi Gligorovic, Paul Kundzicz, Maria T. Acosta, Philip Shaw (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13287277.txt.
Description
Cristina M Justice and colleagues searched family data in 2026 for inherited variants behind attention deficit hyperactivity disorder. Two family collections were combined, covering more than two thousand people. Tests looked both at single variants passed within families and at broad chromosome regions shared by affected relatives.
Three variant signals passed strict thresholds, near or inside genes called TFRC, GSDME, and TRIM31. One shared region on chromosome 19 held another strong signal. Gene sets also overlapped with brain surface size and with resting brain network measures. The authors say family designs can surface risk genes that ordinary case comparisons miss, and can start linking those genes to brain traits.
Catalog record
| CREATOR | Cristina M. Justice, Kwangmi Ahn, Benjamin Jung, Luke J. Norman, Gustavo Sudre, Wendy Sharp, Marine Bouyssi-Kobar, Saadia Choudhury, Stevi Gligorovic, Paul Kundzicz, Maria T. Acosta, Philip Shaw |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53529 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |