Receptor discordance between primary tumors and nodal metastases and correlation with the 21-gene recurrence score in early-stage, estrogen receptor-positive, node-positive breast cancer
Serena Zheng, Peggy Sullivan, Kumkum Vadehra, Jiyoon Kim, Alexis Levee, Rena Callahan, Mediget Teshome, Chi-Hong Tseng, Aditya Bardia, Nimmi S Kapoor · 2026
Read Receptor discordance between primary tumors and nodal metastases and correlation with the 21-gene recurrence score in early-stage, estrogen receptor-positive, node-positive breast cancer by Serena Zheng, Peggy Sullivan, Kumkum Vadehra, Jiyoon Kim, Alexis Levee, Rena Callahan, Mediget Teshome, Chi-Hong Tseng, Aditya Bardia, Nimmi S Kapoor (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13287169.txt.
Description
Serena Zheng and colleagues checked in 2026 whether hormone markers measured in a breast tumour still match when cancer reaches nearby lymph nodes. They studied women with early, node-positive disease who had surgery first and gene testing on the main tumour between 2016 and 2020.
Archived node tissue was available for 73 patients. At least one marker differed in 77% of cases, most often for HER2, usually by a small amount. No node sample became strongly HER2 positive. Larger tumours and larger node deposits went with bigger HER2 shifts. The gene score itself was not clearly tied to mismatch, so node testing may still add useful information.
Catalog record
| CREATOR | Serena Zheng, Peggy Sullivan, Kumkum Vadehra, Jiyoon Kim, Alexis Levee, Rena Callahan, Mediget Teshome, Chi-Hong Tseng, Aditya Bardia, Nimmi S Kapoor |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41150 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |