The role of interferon regulatory factors in atherosclerosis: from cell type-specific mechanisms to therapeutic strategies
Jie Huang, Jia Wang, Hong Chen, Fuqiang Guo, Xiaofan Yuan · 2026
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Description
Jie Huang and colleagues review the interferon regulatory factor family, nine gene switches that coordinate immune and metabolic activity, as players in atherosclerosis. Their 2026 article maps each family member's role in the artery wall, where plaques form, grow, and sometimes rupture. Several members fan inflammation, activating vessel lining cells and pushing macrophages toward aggressive states.
Other members calm the system, restraining interferon signals and supporting orderly cleanup and regulatory T cells. Two members behave differently depending on cell type and context. Treatment ideas range from small-molecule blockers and epigenetic drugs to microRNA therapies and dietary compounds. Because these switches also defend against viruses, future drugs must target specific cells rather than the whole body.
Catalog record
| CREATOR | Jie Huang, Jia Wang, Hong Chen, Fuqiang Guo, Xiaofan Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |