Cervical Metastasis From Primary Breast Carcinoma: A Case Report and Review of Extragenital Tumors Involving the Uterine Cervix
Mario Assenza, Adele Zappalà, Armando Nallbani, Jacopo Wabersich · 2026
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Description
Mario Assenza and co-authors trace breast cancer's rare spread to the uterine cervix in a 2026 case report and literature review. A 59-year-old woman treated in 2015 for hormone-sensitive ductal breast cancer, with surgery, chemotherapy, radiation, and endocrine therapy, later saw a tumor marker climb and settle near four times its ceiling. Bleeding prompted imaging that lit up a metabolically active lesion in her uterus.
Biopsies of womb and cervix returned a poorly differentiated carcinoma matching her breast primary's lineage rather than a new uterine cancer. Marker stains for mammary origin, including GATA3 and mammaglobin, anchor the diagnosis in their review. The tumor's receptor profile had flipped since 2015, a discordance the authors say makes re-biopsy essential. She began combined chemotherapy and immunotherapy in March 2024, tolerating it well as treatment continues.
Catalog record
| CREATOR | Mario Assenza, Adele Zappalà, Armando Nallbani, Jacopo Wabersich |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27190 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |