Multimodal MRI reveals three-tiered pathological co-alterations in prolonged disorders of consciousness: structural disconnection, network disintegration, and regional hyperconnectivity
Xiyong Wang, Yi Yin, Xianbin Wang, Shuang Wu · 2026
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Description
Xiyong Wang and co-authors scanned the brains of eighteen patients with prolonged disorders of consciousness, conditions where awareness stays impaired for weeks after severe injury. The 2026 study used resting brain scans plus imaging of white matter wiring. Bedside behavior scales can miss hidden awareness, so objective brain measures could improve diagnosis and prognosis.
Compared with twenty healthy volunteers, patients showed damaged wiring in a left frontal pathway, broken communication among higher cortical networks, and unusual overactivity in the cerebellum and limb regions. Scores on a standard recovery scale tracked with the wiring measure and some activity patterns. The authors frame the disorder as three layers of change at once: disconnection, network breakup, and local overconnection.
Catalog record
| CREATOR | Xiyong Wang, Yi Yin, Xianbin Wang, Shuang Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |