mmu_circ_0012122/mmu-miR-1843-5p/Sertad2 axis: A novel regulatory pathway in rabies virus infection
Qianni Ye, Xinggang Tang, Haiming Cai, Minggui Yuan, Xiaomin Ba, Ya Tian, Jing Chen, Xiaohu Wang, Rong Xiang · 2026
Read mmu_circ_0012122/mmu-miR-1843-5p/Sertad2 axis: A novel regulatory pathway in rabies virus infection by Qianni Ye, Xinggang Tang, Haiming Cai, Minggui Yuan, Xiaomin Ba, Ya Tian, Jing Chen, Xiaohu Wang, Rong Xiang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13285605.txt.
Description
A ring-shaped RNA acts as a sponge that steers nerve cell death in rabies, Qianni Ye and co-authors uncover in a 2026 mouse study. Rabies virus wrecks the brain, yet its inner tricks stay murky. Brains of mice infected with two virus strains were compared with clean brains to hunt changed ring RNAs.
Over thirteen hundred rings shifted, mostly born from coding gene parts and tied to synapse paths. One ring soaked up a tiny RNA partner, freeing a gene called Sertad2 to rise. Silencing the ring cut nerve cell death, while boosting the tiny partner calmed both death routes. Sertad2 itself fanned cell death and brain swelling. The authors name the trio a drug target lead.
Catalog record
| CREATOR | Qianni Ye, Xinggang Tang, Haiming Cai, Minggui Yuan, Xiaomin Ba, Ya Tian, Jing Chen, Xiaohu Wang, Rong Xiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71575 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |