Nanocarrier-mediated targeting of NF-κB and JAK/STAT signaling pathways in hepatocellular carcinoma: mechanisms and therapeutic strategies
Muhammad Azhar, Yang Duan, Muhammad Ahmad, Haichuan Wang · 2026
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Description
Muhammad Azhar and co-authors review tiny carriers that deliver drugs to liver cancer cells, in a paper from 2026. This cancer, called hepatocellular carcinoma, is a major cause of cancer death. Two cell signal paths, known as NF-κB and JAK/STAT, are often overactive in it and help the cancer grow, hide, and resist drugs.
The review covers carrier types made from polymers, fats, minerals, and cell-like shells. These carriers can hold small drugs, gene material, or paired treatments and release them in a controlled way. Some are fitted with guides that home to liver tissue. Blocking both signal paths at once raised anti-tumor effects and lowered harm to the rest of the body in early studies. Scale-up, safety, and rules remain open issues.
Catalog record
| CREATOR | Muhammad Azhar, Yang Duan, Muhammad Ahmad, Haichuan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |