Dual-mechanism therapy for chronic rhinosinusitis via siRNA targeting of bacterial 16S rRNA and disruption of CFTR-pathogen interactions
Bo Wei, Jiaoyu He, Jiaxin Li, Feng Liu · 2026
Read Dual-mechanism therapy for chronic rhinosinusitis via siRNA targeting of bacterial 16S rRNA and disruption of CFTR-pathogen interactions by Bo Wei, Jiaoyu He, Jiaxin Li, Feng Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13285275.txt.
Description
Bo Wei, Jiaoyu He, Jiaxin Li, and Feng Liu report a 2026 laboratory study on a dual attack against chronic rhinosinusitis. Long-term sinus swelling affects about one in ten adults in many regions and cuts life quality. The team designed small RNA pieces to silence bacterial 16S ribosomal RNA and to block links between a host channel protein and pathogens.
Docking models showed a strong blocking contact for the paired design in the computer checks reported here. In cell tests, the small RNA cut target 16S expression by about two thirds. The authors present the dual plan as a first step toward precise, microbe-focused therapy for stubborn sinus disease, while noting early-stage proof only.
Catalog record
| CREATOR | Bo Wei, Jiaoyu He, Jiaxin Li, Feng Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31981 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |