Growth plate cartilage-targeting nanoparticles for pharmacological treatment of hypochondroplasia
Shang-Hui Ye, Lian-Jie Li, Yi-Jiao Wang, Cheng-Run Yuan, Jie Han, Dan He, Lin Che, Xiao-Hui Chen, Rong Shen, Jian Yang, Matthew B Greenblatt, Xian-Xian Yang, Jian-Min Huang, Jing Chen, Ren Xu · 2026
Read Growth plate cartilage-targeting nanoparticles for pharmacological treatment of hypochondroplasia by Shang-Hui Ye, Lian-Jie Li, Yi-Jiao Wang, Cheng-Run Yuan, Jie Han, Dan He, Lin Che, Xiao-Hui Chen, Rong Shen, Jian Yang, Matthew B Greenblatt, Xian-Xian Yang, Jian-Min Huang, Jing Chen, Ren Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13284457.txt.
Description
Shang-Hui Ye and colleagues report a 2026 drug delivery study for hypochondroplasia, a cartilage disorder that causes short stature. Gain-of-function changes in FGFR3 overdrive growth plate signals, yet the plate lacks blood vessels, so drugs reach it poorly. The team coated nanoparticles with chondrocyte membranes and added a collagen II binding peptide to target cartilage.
In a mouse model, the particles carried a Hedgehog pathway drug to the growth plate. Treated mice showed stronger Hedgehog signals, better cilia repair, healthier cartilage cell traits, and longer bones and bodies. The authors present the platform as a promising way to deliver drugs to hard-to-reach growth plate tissue.
Catalog record
| CREATOR | Shang-Hui Ye, Lian-Jie Li, Yi-Jiao Wang, Cheng-Run Yuan, Jie Han, Dan He, Lin Che, Xiao-Hui Chen, Rong Shen, Jian Yang, Matthew B Greenblatt, Xian-Xian Yang, Jian-Min Huang, Jing Chen, Ren Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70204 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |