Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer
Min-Ying Lin, Jyh-Der Leu, Chun-Yi Wu, Liang-Cheng Chen, Yi-Jang Lee · 2026
Read Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer by Min-Ying Lin, Jyh-Der Leu, Chun-Yi Wu, Liang-Cheng Chen, Yi-Jang Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13284410.txt.
Description
Min-Ying Lin and co-authors design a peptide that slows the spread of lung cancer, in a 2026 study. Spread, or metastasis, drives most deaths from non-small cell lung cancer. Cancer cells move by rebuilding their actin skeleton, a process steered by a protein pair: the enzyme LIMK and its target, cofilin-1. Data scans tied high levels of the pair to poor patient outcomes.
The team built a mimic peptide that acts as a decoy for the enzyme. The peptide gathered in lung cancer cells with high enzyme levels, in dishes and in mice. It loosened actin stress fibers, which cut cell movement and invasion. In mouse models of lung cancer in place, spread fell and survival lengthened. No broad toxicity appeared. The authors propose the decoy route as a therapy lead for metastatic disease.
Catalog record
| CREATOR | Min-Ying Lin, Jyh-Der Leu, Chun-Yi Wu, Liang-Cheng Chen, Yi-Jang Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |