Melatonin-treated bone marrow mesenchymal stem cell-derived exosomes reverse liver fibrosis induced by CCl4 in male wistar albino rats
Naglaa W. Abdelbaky, Ahmed Nabil, Osama M. Ahmed, Mohamed I. Zanaty · 2026
Read Melatonin-treated bone marrow mesenchymal stem cell-derived exosomes reverse liver fibrosis induced by CCl4 in male wistar albino rats by Naglaa W. Abdelbaky, Ahmed Nabil, Osama M. Ahmed, Mohamed I. Zanaty (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13284369.txt.
Description
Naglaa W. Abdelbaky and co-authors test a cell-based treatment for liver scarring in rats in a 2026 animal study. The treatment used exosomes from bone marrow stem cells that had first been treated with melatonin. Rats with liver fibrosis from carbon tetrachloride got the exosomes by vein twice a week for four weeks.
Treated rats showed better liver enzyme and albumin levels, plus stronger antioxidant markers such as SOD activity and Nrf2. Harmful markers linked to swelling, cell death, and scarring fell, and tissue checks showed less collagen and less inflamed tissue. The findings suggest melatonin priming may boost the healing value of stem cell exosomes, though the work stays at the animal stage.
Catalog record
| CREATOR | Naglaa W. Abdelbaky, Ahmed Nabil, Osama M. Ahmed, Mohamed I. Zanaty |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47231 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |