Multi-omics analysis of kidney renal cell carcinoma in silico with preliminary in vivo validation
Tingyu Su, Fan Jiang, Jianjun Gao, Xiubin Li, Hongmei Cheng, Yang Wang · 2026
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Description
Tingyu Su and colleagues combined many data types in 2026 to hunt prognostic markers in clear cell kidney cancer, the main kidney cancer form, which carries a poor outlook. Genome, methylation, and immune data from public databases were merged, then checked with single-cell sequencing, genetic causal analysis, computer gene knockout, and lab tests.
One gene, CRHBP, stood out as switched down in tumours, with lower levels at later stages and a link to better survival when levels held up. A partner signal, UCN2 from the testes, showed a causal risk effect and tied inversely to vessel growth and low oxygen in tumours. Computer docking flagged an existing drug, dabrafenib, as a candidate binder for both targets. Lab checks confirmed the expression shifts in human and mouse tissue.
Catalog record
| CREATOR | Tingyu Su, Fan Jiang, Jianjun Gao, Xiubin Li, Hongmei Cheng, Yang Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |