Evaluation of a strain Long human respiratory syncytial virus with M2–2 gene deletion in intranasally vaccinated BALB/c mice
Ri-gan Shu, Jie Jun, Yun-xuan Zheng, Dan-ning Yue, Hao Hu, Hua-wei Xu, Xiao-lei Zhao, Hong-ru Wang, Xi-man Liu, Yi-peng Zhang, He Wang, Jie-mei Yu, Yan-peng Zheng, Xiang-lei Peng, Yuan-hui Fu, Jin-sheng He · 2026
Read Evaluation of a strain Long human respiratory syncytial virus with M2–2 gene deletion in intranasally vaccinated BALB/c mice by Ri-gan Shu, Jie Jun, Yun-xuan Zheng, Dan-ning Yue, Hao Hu, Hua-wei Xu, Xiao-lei Zhao, Hong-ru Wang, Xi-man Liu, Yi-peng Zhang, He Wang, Jie-mei Yu, Yan-peng Zheng, Xiang-lei Peng, Yuan-hui Fu, Jin-sheng He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13283998.txt.
Description
Ri-gan Shu and a large team evaluated weakened vaccine strains of respiratory syncytial virus in 2026 in mice. RSV is a leading cause of serious chest illness in infants and older people, yet no licensed vaccine exists for young infants. The team deleted a viral gene called M2-2 from a long-used lab strain, and built a second version with extra changes in another gene.
Both engineered viruses grew less well in cell culture than the parent virus. In mice, the single-deletion strain left lower lung virus loads and less weight loss than the double-change version. Given through the nose, it raised strong antibody and T cell responses with a Th1 lean, and it protected mice against a later RSV challenge with no signs of worsened disease. The authors back this strain for further development.
Catalog record
| CREATOR | Ri-gan Shu, Jie Jun, Yun-xuan Zheng, Dan-ning Yue, Hao Hu, Hua-wei Xu, Xiao-lei Zhao, Hong-ru Wang, Xi-man Liu, Yi-peng Zhang, He Wang, Jie-mei Yu, Yan-peng Zheng, Xiang-lei Peng, Yuan-hui Fu, Jin-sheng He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |