PLGA/SF/linagliptin wound matrix-induced membrane promotes diabetic wounds healing by inhibiting macrophage pyroptosis
Yizhuo Ren, Yanlong Wang, Kaixuan Cai, Xianzheng Lin, Tao Tang, Meng Yin · 2026
Read PLGA/SF/linagliptin wound matrix-induced membrane promotes diabetic wounds healing by inhibiting macrophage pyroptosis by Yizhuo Ren, Yanlong Wang, Kaixuan Cai, Xianzheng Lin, Tao Tang, Meng Yin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13283444.txt.
Description
Yizhuo Ren and co-authors build a drug-loaded membrane that speeds healing of diabetic wounds in this 2026 paper. Such wounds stall in the inflammation phase. A fiery cell-death route called pyroptosis, active in macrophages, keeps the fire burning. The team spun fibers of two polymers with silk protein and loaded them with linagliptin.
The membrane released the drug slowly and suited living tissue well. In cell tests, linagliptin calmed macrophage pyroptosis through a side pathway and cut inflammatory output. Wound-healing cells worked better as a result. In diabetic animals, covered wounds closed faster, spent less time inflamed, and regrew skin of better quality.
Catalog record
| CREATOR | Yizhuo Ren, Yanlong Wang, Kaixuan Cai, Xianzheng Lin, Tao Tang, Meng Yin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |