HIV Reservoirs in Brain parenchyma and Cerebrospinal Fluid During Suppressive ART: Same-Same or Very Different?
Thomas A. Angelovich, Janna Jamal Eddine, Emily K. Chalmers, Sarah J. Byrnes, Melissa J. Churchill · 2026
Read HIV Reservoirs in Brain parenchyma and Cerebrospinal Fluid During Suppressive ART: Same-Same or Very Different? by Thomas A. Angelovich, Janna Jamal Eddine, Emily K. Chalmers, Sarah J. Byrnes, Melissa J. Churchill (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13283176.txt.
Description
HIV hiding in brain tissue differs from HIV in spinal fluid, a distinction Thomas A Angelovich and fellow reviewers press in 2026. Even when drugs suppress HIV, virus can persist in the central nervous system. Such persistence may drive inflammation and thinking problems that last for years.
Recent work found intact and faulty HIV DNA in brain tissue and spinal fluid. Virus from both sites can still make proteins and restart spread without drugs. Brain tissue and spinal fluid differ in cell sources and reservoir behavior. Those gaps may shape distinct effects on brain health and cognition. The review urges cure research to treat each brain region on its own terms, not as one pool.
Catalog record
| CREATOR | Thomas A. Angelovich, Janna Jamal Eddine, Emily K. Chalmers, Sarah J. Byrnes, Melissa J. Churchill |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29777 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |