Targeting QRICH1 suppresses epithelial-mesenchymal transition and tumor growth in liver cancer through the Connexin43/USP1 mediated Snail1 stabilization
Su-Yeon Park, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim · 2026
Read Targeting QRICH1 suppresses epithelial-mesenchymal transition and tumor growth in liver cancer through the Connexin43/USP1 mediated Snail1 stabilization by Su-Yeon Park, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13282892.txt.
Description
QRICH1, a protein tied to cell stress, is put under the microscope for liver cancer by Su-Yeon Park and co-workers in 2026. QRICH1 has been linked to cell stress and to a process that helps cancer cells move. Its exact role in liver cancer was not clear.
QRICH1 was high in liver tumor tissue and linked to poor outcomes. Silencing it cut cell growth, movement, invasion, and spread traits in lab tests. QRICH1 bound Snail1 and USP1 and kept Snail1 stable by blocking its removal. It also lowered Connexin43 and weakened direct cell contact signals. In mice, silencing QRICH1 slowed tumor growth and restored markers of less aggressive cells.
Catalog record
| CREATOR | Su-Yeon Park, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49827 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |