Acute Encephalopathy in Multiple Sclerosis With Renal Failure: Synergistic Neurotoxicity of Baclofen and Meropenem
Bernacchia D, Rigoni M, Canavesi G, Franzetti M, Pagani G, Bassani F, Verrengia E, Gottardo R, Di Toma L F, Pavia C, Rusconi S, Rajib Chowdhury · 2026
Read Acute Encephalopathy in Multiple Sclerosis With Renal Failure: Synergistic Neurotoxicity of Baclofen and Meropenem by Bernacchia D, Rigoni M, Canavesi G, Franzetti M, Pagani G, Bassani F, Verrengia E, Gottardo R, Di Toma L F, Pavia C, Rusconi S, Rajib Chowdhury (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13282454.txt.
Description
Bernacchia D and co-authors describe a 2026 case where two drugs together likely poisoned the brain of a man with multiple sclerosis and kidney failure. Multiple sclerosis is an autoimmune disease damaging nerve insulation in brain and spinal cord. The patient, a sixty-two-year-old man, was taking meropenem, an antibiotic, for a urinary infection. He developed confusion, seizures, and abnormal brain wave patterns, first blamed on the antibiotic alone.
Closer review found an overdose of baclofen, a muscle relaxant he had used for years for stiffness. Poor kidney function would slow clearance of both drugs. Both act on the GABA system, the brain's main calming signal, so their toxic effects may have reinforced each other. The authors call the combined picture acute metabolic encephalopathy, sudden brain dysfunction from body chemistry.
Catalog record
| CREATOR | Bernacchia D, Rigoni M, Canavesi G, Franzetti M, Pagani G, Bassani F, Verrengia E, Gottardo R, Di Toma L F, Pavia C, Rusconi S, Rajib Chowdhury |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18552 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |