Prognostic associations between patient-reported outcomes and overall survival among patients with advanced squamous non-small cell lung cancer: results from the RATIONALE-307 trial
Jie Wang, Xinmin Yu, Shiangjiin Leaw, Frederick B Barnes, Timothy Victor, Gisoo Barnes · 2026
Read Prognostic associations between patient-reported outcomes and overall survival among patients with advanced squamous non-small cell lung cancer: results from the RATIONALE-307 trial by Jie Wang, Xinmin Yu, Shiangjiin Leaw, Frederick B Barnes, Timothy Victor, Gisoo Barnes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13282351.txt.
Description
Jie Wang and co-authors present a 2026 analysis from a lung cancer drug trial on how patient-reported symptoms relate to survival. The trial tested an immune therapy drug, tislelizumab, added to chemotherapy, against chemotherapy alone. Patients had advanced squamous non-small cell lung cancer, a common lung cancer type. Earlier results favoured the combined treatment for survival and quality of life.
Three hundred twenty-eight patients were included across three treatment arms. Both combined arms improved overall quality of life scores against chemotherapy alone. Breathing difficulty improved in both, while chest pain improved in only one combination. In one arm, improvement in chest pain and cough each linked to about a third lower risk of death. The authors used a joint statistical model to connect symptom change, symptom flare events, and survival. They argue that how patients feel carries information about how long they may live.
Catalog record
| CREATOR | Jie Wang, Xinmin Yu, Shiangjiin Leaw, Frederick B Barnes, Timothy Victor, Gisoo Barnes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46235 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |