Optimizing Colistin Sulfate Dosing in Severe Infections: A Population Pharmacokinetic Model-Guided Approach
Yingchao Ma, Yongjing Wang, Xia Wu, Jin Wang, Yimeng Pang, Yaqiang Jia, Xiuling Yang, Jianjun Gu · 2026
Read Optimizing Colistin Sulfate Dosing in Severe Infections: A Population Pharmacokinetic Model-Guided Approach by Yingchao Ma, Yongjing Wang, Xia Wu, Jin Wang, Yimeng Pang, Yaqiang Jia, Xiuling Yang, Jianjun Gu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13281951.txt.
Description
Yingchao Ma and colleagues built a dosing model for a last-resort antibiotic in a 2026 study. The drug revives old power against germs that resist modern standbys. Its safe band is narrow, and levels swing widely between patients. The team enrolled fifty-one very ill patients with drug-proof infections at a Hebei hospital. Care ran from 2021 to 2023. Blood readings, one hundred twenty-three in all, fed the model. Computer runs then tested doses across kidney strength and germ toughness.
About six in ten patients improved in care, and about half cleared their germs. Kidney harm was rare, in two patients. A one-room model fit the drug's path, with kidney strength as the key dial. Standard doses hit the target zone reliably only for the most sensitive germs in normal kidneys. Tougher germs or weaker kidneys broke the target. The authors offer it as a dosing guide.
Catalog record
| CREATOR | Yingchao Ma, Yongjing Wang, Xia Wu, Jin Wang, Yimeng Pang, Yaqiang Jia, Xiuling Yang, Jianjun Gu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50893 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |