Association Between Hemostatic Profiles and Hypertensive Disorders of Pregnancy: A Multi-Omics Mendelian Randomization Study
Yixuan Li, Xianglin Long, Yeshen Zhang, Shan Tu, Wenzhi Luo, Xiaoyan Wang, Lixiong Zeng, Fei Ye, Xu Deng, Zhihui Zhang · 2026
Read Association Between Hemostatic Profiles and Hypertensive Disorders of Pregnancy: A Multi-Omics Mendelian Randomization Study by Yixuan Li, Xianglin Long, Yeshen Zhang, Shan Tu, Wenzhi Luo, Xiaoyan Wang, Lixiong Zeng, Fei Ye, Xu Deng, Zhihui Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13281770.txt.
Description
Yixuan Li and colleagues used gene data to probe clotting and pregnancy blood pressure in a 2026 study. High blood pressure in pregnancy can kill mothers worldwide. Its worst form brings seizures and organ strain. Clotting switches on in that illness, but whether clotting drives it is unclear. The team used genes as natural levers, since genes are fixed before illness. They checked clotting traits and blood proteins against illness risk in large gene datasets.
First passes hinted at links. Higher levels of two clotting factors went with higher risk. Lower levels of a clotting brake went with higher risk too. Extra checks found no wide bias in the data. But when the team applied the strictest error bar, none of the links held firm. A sharing test also gave low odds that the same gene spot drives both traits. The authors call the proof suggestive at best.
Catalog record
| CREATOR | Yixuan Li, Xianglin Long, Yeshen Zhang, Shan Tu, Wenzhi Luo, Xiaoyan Wang, Lixiong Zeng, Fei Ye, Xu Deng, Zhihui Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45723 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |